Manifestaciones clínicas del síndrome de apnea obstructiva del sueño según el sexo en pacientes adultos con COVID prolongado en Magallanes y la Región Antártica Chilena: análisis basado en el cuestionario STOP-BANG.
DOI:
https://doi.org/10.71112/4vhh6w50Palavras-chave:
Zona Extrema, Síndrome de Apnea Obstructiva del sueño, Long Covid, Stop BangResumo
El síndrome de apnea obstructiva del sueño (SAOS) es una condición respiratoria crónica asociada a consecuencias cardiovasculares, metabólicas y neurocognitivas. Tras la pandemia de COVID-19, diversos reportes han documentado un aumento de alteraciones del sueño en personas con Long COVID, incluyendo manifestaciones compatibles con SAOS. Este estudio tuvo como objetivo analizar diferencias en la expresión sintomática del SAOS entre hombres y mujeres adultos con diagnóstico de Long COVID, mediante el cuestionario STOP-BANG.
MÉTODOS: Diseño observacional, transversal y descriptivo, con una muestra de 104 pacientes atendidos en el Centro Asistencial Docente e Investigación de la Universidad de Magallanes (CADI-UMAG).
RESULTADOS: Se observó una mayor frecuencia de síntomas respiratorios en hombres y una presentación clínica menos evidente en mujeres.
CONCLUSIÓN: Estas diferencias refuerzan la necesidad de estrategias diagnósticas adaptadas al perfil sintomatológico destacando la utilidad del cuestionario STOP-BANG para detectar riesgo de SAOS en pacientes post-COVID-19.
Downloads
Referências
Carrillo, A. J., Vargas, R. C., Cisternas, V. A., & Olivares-Tirado, P. (2017). Prevalencia de riesgo de apnea obstructiva del sueño en población adulta chilena. Revista Chilena de Enfermedades Respiratorias, 33(4). DOI: https://doi.org/10.4067/S0717-73482017000400275
Chiner-Vives, E., Cordovilla-Pérez, R., de la Rosa-Carrillo, D., García-Clemente, M., Izquierdo-Alonso, J. L., Otero-Candelera, R., et al. (2022). Short- and long-term impact of COVID-19 infection on previous respiratory diseases. Archivos de Bronconeumología, 58, 39–50. DOI: https://doi.org/10.1016/j.arbres.2022.03.011
Chinvararak, C., & Chalder, T. (2023). Prevalence of sleep disturbances in patients with long COVID assessed by standardised questionnaires and diagnostic criteria: A systematic review and meta-analysis. Journal of Psychosomatic Research, 175, 111536. DOI: https://doi.org/10.1016/j.jpsychores.2023.111535
Chung, F., Abdullah, H. R., & Liao, P. (2016). STOP-Bang questionnaire. Chest, 149(3), 631–638. https://doi.org/10.1378/chest.15-0903 DOI: https://doi.org/10.1378/chest.15-0903
Cruces-Artero, C., Hervés-Beloso, C., Martín-Miguel, V., Hernáiz-Valero, S., Lago-Deibe, F. I., Montero-Gumucio, M., et al. (2019). Utilidad diagnóstica del cuestionario STOP-Bang en la apnea del sueño moderada en atención primaria. Gaceta Sanitaria, 33(5), 456–462. DOI: https://doi.org/10.1016/j.gaceta.2018.05.003
George, D., & Mallery, P. (2021). IBM SPSS Statistics 27 step by step: A simple guide and reference. Routledge. DOI: https://doi.org/10.4324/9781003205333
González Jaimes, N. L., & Tláhuext Aca, J. F. (2024). Circunferencia del cuello como predictor del sobrepeso y obesidad en jóvenes universitarios mexicanos. International Journal of Kinanthropometry, 4(2), 13–21. DOI: https://doi.org/10.34256/ijk2422
Hingorjo, M. R., Qureshi, M. A., & Mehdi, A. (2012). Neck circumference as a useful marker of obesity: A comparison with body mass index and waist circumference. Journal of the Pakistan Medical Association, 62(1), 36–40.
Ho, A. W., Moul, D. E., & Krishna, J. (2016). Neck circumference–height ratio as a predictor of sleep-related breathing disorder in children and adults. Journal of Clinical Sleep Medicine, 12(3), 311–317. DOI: https://doi.org/10.5664/jcsm.5572
Hwang, M., Nagappa, M., Guluzade, N., Saripella, A., Englesakis, M., & Chung, F. (2022). Validation of the STOP-Bang questionnaire as a preoperative screening tool for obstructive sleep apnea: A systematic review and meta-analysis. BMC Anesthesiology, 22(1), 366. https://doi.org/10.1186/s12871-022-01874-3 DOI: https://doi.org/10.1186/s12871-022-01912-1
IBM Corp. (2019). IBM SPSS Statistics for Windows (Version 26.0). IBM Corp.
Leng, Y., McEvoy, C. T., Allen, I. E., & Yaffe, K. (2017). Association of sleep-disordered breathing with cognitive function and risk of cognitive impairment. JAMA Neurology, 74(10), 1237–1245. https://doi.org/10.1001/jamaneurol.2017.2180 DOI: https://doi.org/10.1001/jamaneurol.2017.2180
McGuire, W. C., Pearce, A. K., & Malhotra, A. (2023). Sleep disturbances, dyspnoea, and anxiety in long COVID. The Lancet Respiratory Medicine, 11(8), 664–665. https://doi.org/10.1016/S2213-2600(23)00213-6 DOI: https://doi.org/10.1016/S2213-2600(23)00138-8
Mihaicuta, S., Udrescu, L., Udrescu, M., Toth, I. A., Topîrceanu, A., Pleavă, R., et al. (2021). Analyzing neck circumference as an indicator of CPAP treatment response in obstructive sleep apnea with network medicine. Diagnostics, 11(1), 86. https://doi.org/10.3390/diagnostics11010086 DOI: https://doi.org/10.3390/diagnostics11010086
Nagappa, M., Liao, P., Wong, J., Auckley, D., Ramachandran, S. K., Memtsoudis, S., et al. (2015). Validation of the STOP-Bang questionnaire as a screening tool for obstructive sleep apnea among different populations: A systematic review and meta-analysis. PLOS ONE, 10(12), e0143697. https://doi.org/10.1371/journal.pone.0143697 DOI: https://doi.org/10.1371/journal.pone.0143697
Nagappa, M., Wong, J., Singh, M., Wong, D. T., & Chung, F. (2017). An update on the various practical applications of the STOP-Bang questionnaire in anesthesia, surgery, and perioperative medicine. Current Opinion in Anaesthesiology, 30(1), 118–125. https://doi.org/10.1097/ACO.0000000000000426 DOI: https://doi.org/10.1097/ACO.0000000000000426
Ojeda, D., Monsalve, V., Cisternas, P., Jorquera, Á., & Mora, K. (2022). Utilidad del cuestionario STOP-BANG como predictor único de vía aérea difícil. Revista Médica de Chile, 150(4), 486–494. DOI: https://doi.org/10.4067/S0034-98872022000400450
Oliveros, E., Patel, H., Kyung, S., Fugar, S., Goldberg, A., Madan, N., et al. (2020). Hypertension in older adults: Assessment, management, and challenges. Clinical Cardiology, 43(2), 99–107. https://doi.org/10.1002/clc.23303 DOI: https://doi.org/10.1002/clc.23303
Pivetta, B., Chen, L., Nagappa, M., Saripella, A., Waseem, R., Englesakis, M., et al. (2021). Use and performance of the STOP-Bang questionnaire for obstructive sleep apnea screening across geographic regions. JAMA Network Open, 4(3), e211009. https://doi.org/10.1001/jamanetworkopen.2021.1009 DOI: https://doi.org/10.1001/jamanetworkopen.2021.1009
Popovici, G. C., Georgescu, C. V., Vasile, M. C., Vlase, C. M., Arbune, A. A., & Arbune, M. (2024). Obstructive sleep apnea after COVID-19: An observational study. Life, 14(8), 1052. https://doi.org/10.3390/life14081052 DOI: https://doi.org/10.3390/life14081052
Quan, S. F., Weaver, M. D., Czeisler, M. É., Barger, L. K., Booker, L. A., Howard, M. E., et al. (2024). Association of obstructive sleep apnea with post-acute sequelae of SARS-CoV-2 infection. The American Journal of Medicine, 137(6), 529–537.e3. https://doi.org/10.1016/j.amjmed.2024.02.023 DOI: https://doi.org/10.1016/j.amjmed.2024.02.023
Scarpelli, S., De Santis, A., Alfonsi, V., Gorgoni, M., Morin, C. M., Espie, C., et al. (2023). The role of sleep and dreams in long COVID. Journal of Sleep Research, 32(3), e13778. https://doi.org/10.1111/jsr.13778 DOI: https://doi.org/10.1111/jsr.13789
Soriano, J. B., Murthy, S., Marshall, J. C., Relan, P., & Díaz, J. V. (2022). A clinical case definition of post-COVID-19 condition by a Delphi consensus. The Lancet Infectious Diseases, 22(4), e102–e107. https://doi.org/10.1016/S1473-3099(21)00703-9 DOI: https://doi.org/10.1016/S1473-3099(21)00703-9
Strausz, S., Kiiskinen, T., Broberg, M., Ruotsalainen, S., Koskela, J., Bachour, A., et al. (2021). Sleep apnoea is a risk factor for severe COVID-19. BMJ Open Respiratory Research, 8(1), e000845. https://doi.org/10.1136/bmjresp-2020-000845 DOI: https://doi.org/10.1136/bmjresp-2020-000845
Taquet, M., Sillett, R., Zhu, L., Mendel, J., Camplisson, I., Dercon, Q., et al. (2022). Neurological and psychiatric risk trajectories after SARS-CoV-2 infection: An analysis of 2-year retrospective cohort studies including 1,284,437 patients. The Lancet Psychiatry, 9(10), 815–827. https://doi.org/10.1016/S2215-0366(22)00260-7 DOI: https://doi.org/10.1016/S2215-0366(22)00260-7
Tedjasukmana, R., Budikayanti, A., Islamiyah, W. R., Witjaksono, A. M. A. L., & Hakim, M. (2023). Sleep disturbance in post-COVID-19 conditions: Prevalence and quality of life. Frontiers in Neurology, 13, 1044541. https://doi.org/10.3389/fneur.2022.1044541 DOI: https://doi.org/10.3389/fneur.2022.1095606
Yuksel, D., McKee, G. B., Perrin, P. B., Alzueta, E., Caffarra, S., Ramos-Usuga, D., et al. (2021). Sleeping when the world locks down: Correlates of sleep health during the COVID-19 pandemic across 59 countries. Sleep Health, 7(2), 134–142. https://doi.org/10.1016/j.sleh.2020.12.008 DOI: https://doi.org/10.1016/j.sleh.2020.12.008
Zhao, Y., Yan, X., Liang, C., Wang, L., Zhang, H., & Yu, H. (2022). Incorporating neck circumference or neck-to-height ratio into the GOAL questionnaire to better detect and describe obstructive sleep apnea with application to clinical decisions. Frontiers in Neuroscience, 16, 902345. https://doi.org/10.3389/fnins.2022.902345 DOI: https://doi.org/10.3389/fnins.2022.1014948
Zhou, J., Li, X., Zhang, T., Liu, Z., Li, P., Yu, N., et al. (2024). Pre-existing sleep disturbances and risk of COVID-19: A meta-analysis. EClinicalMedicine, 74, 102719. https://doi.org/10.1016/j.eclinm.2024.102719 DOI: https://doi.org/10.1016/j.eclinm.2024.102719
Zhou, X., Zhou, B., Li, Z., Lu, Q., Li, S., Pu, Z., et al. (2021). Gender differences of clinical and polysomnographic findings with obstructive sleep apnea syndrome. Scientific Reports, 11(1), 5938. https://doi.org/10.1038/s41598-021-85533-8 DOI: https://doi.org/10.1038/s41598-021-85558-y
Downloads
Publicado
Edição
Seção
Licença
Copyright (c) 2026 Paola Amaro Moya, Jonathan Lühr Henríquez, Wolfrang. Lühr Henríquez, Leyla Huirimilla-Casanova., Alejandra Fernández Elgueta., Héctor Retamal Matus. (Autor/a)
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
